Jellagen and Copner Biotech sign agreement to develop proprietary jellyfish bio-ink for tissue regeneration
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Welsh biotechnology companies Jellagen and Copner Biotech have joined forces in what the companies claim to be a “world first” partnership to combine new bio-inks derived from jellyfish collagen with advanced precision software.
Having secured funding of £ 123,724 from the Wales Commercial R&D Investor Program, SMART Cymru, the partners seek to improve the compatibility, reproducibility and precision of 3D bioprinting using Jellagen’s proprietary Collagen Type 0 bioink and Copner Biotech’s advanced algorithm software.
“We are absolutely delighted to partner with Jordan Copner and his team at Copner Biotech,” said Professor Andrew Mearns Spragg, Founder and Scientific Director of Jellagen. “SMART Cymru has enabled the creation of an exciting collaboration between two high growth Welsh companies at the forefront of exciting technological innovation in 3D software design capability and medical tissue engineering. “
Jellyfish Collagen Bioinks
Jellagen was founded in 2015 with the aim of developing and commercializing marine-derived collagen for 3D bioprinting applications in the fields of medical and scientific research. The company seeks to create sustainable sources of critical biomaterials that do not pose the environmental and human health risks of traditional sources of collagen.
The company has been working on the development of its next-generation type 0 collagen bio-ink, derived from jellyfish collagen, and is seeking partnerships with medical institutions to study the use of the material as a treatment for diseases of the jellyfish. skin and tissue reconstruction.
Jellagen’s biomaterial collagen is extracted from Rhizostoma Pulmo, an ancient species of large jellyfish common in the Irish Sea. According to the company, type 0 collagen has been shown to promote an anti-inflammatory tissue response that produces fewer side effects than traditional mammal-derived collagens, and demonstrates good compatibility and reproducibility for bioprinting applications. .
Jellagen currently markets a line of type 0 collagen products for research purposes and is also developing clinical grade formulations for therapeutic and medical device applications. The company’s current products include collagen-based gels, scaffolds and collagen-coated culture plates.
Create a “paradigm shift” in bioprinting
According to Jellagen and Copner Biotech, their new partnership has “the potential to transform the 3D bioprinting market,” which Verified Market Research Global 3D Bioprinting Market Report predicts it will be worth £ 1.4 billion by 2028.
The partnership will see Jellagen’s Collagen Type 0 bioinker combined with Copner Biotech’s advanced algorithm software to improve the accuracy of the 3D bioprinting process.
Copner Biotech was founded last year with the goal of creating new software platforms for manufacturing products for applications in the 3D cell culture market, such as cancer research and tissue engineering. . The company has since developed a new software operating platform for designing cell culture scaffolds that facilitate oxygen and nutrient gradients, and received a GHP International Life Sciences Award for Innovation earlier this year. .
On October 1, Copner Biotech filed an application with the UK Intellectual Property Office to patent the design and manufacturing flow for the production of 3D Bio scaffolding with its cell adhesion technology to the scaffolding. Going forward, and as part of its new partnership with Jellagen, Copner Biotech will seek to further develop and commercialize its software through the mass production of polymer cell scaffolds and other bioprinting products.
“This is an extremely exciting scientific collaboration between Copner Biotech and Jellagen, and one that reflects the growing importance of 3D bioprinting in the global medical research landscape,” said Jordan Copner, Founder and CEO of Copner Biotech . “Our partnership aims to push the boundaries to advance innovation in biomedical engineering. “
Marine inspired bioprint
As 3D bioprinting continues to attract increasing interest and development, scientists increasingly seek to replicate materials and processes found in the natural world that exhibit desirable properties that cannot be achieved by artificial means. The development of applications of bio-inks and bioprinting derived from marine sources in particular has generated a lot of interest, with several research breakthroughs having taken place recently.
For example, researchers from Rutgers University have soft 3D printed camouflage-ready robots inspired by adaptable cells found in squid, cuttlefish and octopus, while Yamagata University Scientists have developed a 3D printed actuator that could form the basis of a soft jellyfish-like robot.
In June, scientists from Northwestern University discovered a rare type of iron ore in the teeth of a ‘wandering meatloaf’ mollusc and set out to use this discovery to develop bioinks suitable for 3D printing that mimic strength, stiffness and the stylet connection properties of the mollusk. More recently, researchers from Pacific Northwest National Laboratory has developed a new algae-based bio-ink that can be incorporated into fine microscopic pigment powders to produce vivid colors well suited for artistic applications.
Moving away from the development of bioink, the hierarchical structure of limpets has been exploited for the design of 3D printed microneedle patches, and cell-like biomimetic structures with unique energy absorption capabilities have been exploited. 3D printed on the basis of cuttlefish skeletons. Elsewhere, lobster shell patterns have even formed the basis for designs of 3D printed concrete structures.
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Featured Image Shows Jellagen 3D scaffolds create a 3D cell culture environment that allows cells to maintain their morphology, behavior and reactivity in vivo within an in vitro model system. Photo via Jellagen.